GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1322512 | 1 | rs1407488 | chr6:152945777 | VIP | chr6:153071933-153080898:+ | 0.12 | 4.04 | 5.66E-5 | Tonometry |
| BRCA | cis | rs7515577 | 1 | rs1408916 | chr1:92992627 | EVI5 | chr1:92974255-93257961:- | -0.18 | -4.94 | 8.9E-7 | Cholesterol, total |
| BRCA | cis | rs11185790 | 1 | rs1409360 | chr10:91385304 | FLJ37201 | chr10:91451057-91457685:- | -0.18 | -3.89 | 0.000105 | Metabolic traits |
| BRCA | cis | rs6583954 | 1 | rs1409657 | chr10:96414628 | HELLS | chr10:96305543-96361855:+ | 0.12 | 3.59 | 0.000343 | Migraine |
| BRCA | cis | rs2250644 | 1 | rs1412444 | chr10:91002927 | LIPA | chr10:90973328-91174382:- | 0.2 | 7.02 | 3.96E-12 | Fibrinogen levels |
| BRCA | cis | rs2250644 | 1 | rs1412445 | chr10:91002804 | LIPA | chr10:90973328-91174382:- | 0.2 | 6.92 | 8.02E-12 | Fibrinogen levels |
| BRCA | cis | rs141518190 | 1 | rs141518190 | chr15:78900647 | AGPHD1 | chr15:78799906-78829714:+ | -0.16 | -3.73 | 0.000198 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs141518190 | 1 | rs141518190 | chr15:78900647 | CHRNA5 | chr15:78857906-78886458:+ | -0.2 | -6.06 | 1.93E-9 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs11190604 | 1 | rs1417823 | chr10:102227886 | SEC31B | chr10:102246403-102289636:- | 0.28 | 10.94 | 1.79E-26 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs853679 | 1 | rs1419183 | chr6:28242794 | HIST1H4J | chr6:27791903-27792257:+ | -0.17 | -3.4 | 0.000702 | Depression |
| BRCA | cis | rs853679 | 1 | rs1419183 | chr6:28242794 | ZNF187 | chr6:28234788-28245978:+ | -0.15 | -3.59 | 0.000348 | Depression |
| BRCA | cis | rs853679 | 1 | rs1419183 | chr6:28242794 | ZNF323 | chr6:28292517-28324048:- | 0.2 | 3.52 | 0.000447 | Depression |
| BRCA | cis | rs853679 | 1 | rs1419183 | chr6:28242794 | ZNF389 | chr6:28129551-28137375:+ | -0.2 | -3.64 | 0.000282 | Depression |
| BRCA | cis | rs853679 | 1 | rs1419183 | chr6:28242794 | ZSCAN23 | chr6:28393287-28411279:- | 0.17 | 3.53 | 0.000439 | Depression |
| BRCA | cis | rs950880 | 1 | rs1420101 | chr2:102957716 | IL18R1 | chr2:102927962-103015215:+ | 0.09 | 4.07 | 5.0E-5 | Serum protein levels (sST2) |